ParkinsonCanadaV1, Main, Exploration, bibRecord, 002C41

Non‐subtype‐selective opioid receptor antagonism in treatment of levodopa‐induced motor complications in Parkinson's disease

Identifieur interne : 002C41 ( Main/Exploration ); précédent : 002C40; suivant : 002C42

Non‐subtype‐selective opioid receptor antagonism in treatment of levodopa‐induced motor complications in Parkinson's disease

Auteurs : Susan Fox [Royaume-Uni, Canada] ; Montague Silverdale [Royaume-Uni] ; Mark Kellett [Royaume-Uni] ; Rhys Davies [Royaume-Uni] ; Malcolm Steiger [Royaume-Uni] ; Nicholas Fletcher [Royaume-Uni] ; Alan Crossman [Royaume-Uni] ; Jonathan Brotchie [Royaume-Uni, Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-05.

RBID : ISTEX:52F56D397EBA2B6D95AB6074B842C51C4617AED1

English descriptors

KwdEn :
- Parkinson's disease, dyskinesia, motor fluctuations, naloxone, opioids.

Abstract

Opioid peptide transmission is enhanced in the striatum of animal models and Parkinson's disease (PD) patients with levodopa‐induced motor complications. Opioid receptor antagonists reduce levodopa‐induced dyskinesia in primate models of PD; however, clinical trials to date have been inconclusive. A double‐blind, placebo controlled, crossover design study in 14 patients with PD experiencing motor fluctuations was carried out, using the non‐subtype‐selective opioid receptor antagonist naloxone. Naloxone did not reduce levodopa‐induced dyskinesia. The duration of action of levodopa was increased significantly by 17.5%. Non‐subtype‐selective opioid receptor antagonism may prove useful in the treatment of levodopa‐related wearing‐off in PD but not in dyskinesia. © 2003 Movement Disorder Society

Url:

https://api-v5.istex.fr/document/52F56D397EBA2B6D95AB6074B842C51C4617AED1/fulltext/pdf

DOI: 10.1002/mds.10693

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001A85
to stream Istex, to step Curation: 001A85
to stream Istex, to step Checkpoint: 000D58
to stream Main, to step Merge: 003002
to stream Main, to step Curation: 002C41

Le document en format XML

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<front><div type="abstract" xml:lang="en">Opioid peptide transmission is enhanced in the striatum of animal models and Parkinson's disease (PD) patients with levodopa‐induced motor complications. Opioid receptor antagonists reduce levodopa‐induced dyskinesia in primate models of PD; however, clinical trials to date have been inconclusive. A double‐blind, placebo controlled, crossover design study in 14 patients with PD experiencing motor fluctuations was carried out, using the non‐subtype‐selective opioid receptor antagonist naloxone. Naloxone did not reduce levodopa‐induced dyskinesia. The duration of action of levodopa was increased significantly by 17.5%. Non‐subtype‐selective opioid receptor antagonism may prove useful in the treatment of levodopa‐related wearing‐off in PD but not in dyskinesia. © 2003 Movement Disorder Society</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Non‐subtype‐selective opioid receptor antagonism in treatment of levodopa‐induced motor complications in Parkinson's disease

Non‐subtype‐selective opioid receptor antagonism in treatment of levodopa‐induced motor complications in Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri